Hui-Chen Wu, DrPH
- Assistant Professor of Environmental Health Sciences CUMC
Overview
Dr. Wu's research involves examining the relationship between DNA methylation markers and risk of hepatocellular carcinoma as well as breast cancer and understanding risk factors that may modulate the DNA methylation changes.
Dr. Wu also directs a biomarker core laboratory that processes and stores of biospecimens for clinical trials conducted within Columbia's Herbert Irving Comprehensive Cancer Cancer.
Office Location: 630 West 168th Street, VP&S Room 16-421E
Academic Appointments
- Assistant Professor of Environmental Health Sciences CUMC
Administrative Titles
- Co-Director Translational Research Support Core, Columbia Center for Environmental Health and Justice in Northern Manhattan
- Director Biomarkers Shared Resources, Herbert Irving Comprehensive Cancer Center
Credentials & Experience
Education & Training
- DrPH, 2007 Columbia University Mailman School of Public Health
Research
Research Interests
- Cancer
- Chronic disease
- Community Health
- Disparities/Inequalities in Health
- Environmental Health
- Genetics
- Global Health
- Liver Cancer
Selected Publications
Bezalel Bacon, Mikhail Repin, Igor Shuryak, Hui-Chen Wu, Regina Santella, Mary Beth Terry, David Brenner, Helen C Turner. (2023). High-throughput measurement of double-strand break (DSB) global repair phenotype in peripheral blood lymphocytes after long-term cryopreservation. Cytometry Part A. PMID:36823754. PMCID:PMC10680149
Monique Slowly, Arce Domingo Relloso, Regina Santella, Karin Hacck, Daniele, Mary Beth Terry, Dorothy A. Rhoades, Miguel Herreros-Martinez, Esther Garcia-Esquinas, Shelley A. Cole, Maria Tellez-Plaza, Ana Navas-Acien, Hui-Chen Wu, (2023). Blood DNA methylation and liver cancer in American Indians: the evidence from Strong Heart Study. Cancer Causes& Control.PMID:38010586. PMCID:PMC10960679
Manal M. Hassan, Donghui Li, et al (2024). Genome-Wide Association Study Identifies High-Impact Susceptibility Loci for Hepatocellular Carcinoma in North America. Hepatology. PMID:38381705
Hui-Chen Wu, Hwai-I Yagn, Qiao Wang, Chien-Jen Chen, Regina M. Santella (2017). Plasma DNA Methylation Marker and Hepatocellular Carcinoma Risk Prediction Model for the General Population. Carcinogenesis. 38: 1021-1028. PMID: 28981677; PMCID: PMC582336
Hui-Chen Wu, Laura A. Brennan, Mandy Goldberg, Wendy K. Chung, Irene L. Andrulis, Angela R. Bradbuty, Easter M. John, Mary B Daly, Sundra S Buys, Regina M. Santella, Mary Beth Terry (2020). Influence of Puberty Department on Urinary Oxidative Stress Biomarkers in Adolescent Girls in the New York LEGACY Cohort. Free Radical Research.54:431-441; PMID: 32686531; PMCID:PMC7731215
Hui-Chen Wu, Jing Shen, Abby Siegel, Regina Santella. (2021) Environmental Exposure and clinical correlates of hepatocellular carcinoma in New York City: A case only study. Cancer Cause & Control. PMID:34498221; PMCID:PMC8786455
Maya Spaur, Anne E Nigra, Tiffany R Sanchez, Ana Navas-Acien, Mariana Lazo Lizondo, Hui-Chen Wu (2022). Association of blood Manganese with subclinical measures of liver disease in NHANES 2017-2018. Environmental Research. PMID:35691383
Hui-Chen Wu, Wen-Juei Jeng, Mei-Hung Pan, Yi-Chung Hsieh, Sheng-Nan Lu, Chien-Jen Chen, Hwai-I Yang (2022). Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic hepatitis B/C virus infection. JHEP Reports. PMID:35079699; PMCID:PMC8777288
Hui-Chen Wu, Rebecca Kehm, Regina Santella, David J Brenner, Mary Beth Terry (2022). DNA damage and repair and Cancer Risk: a systematic review and meta-analysis of 55 case-control studies. Scientific Reports. PMCID:PMC8888613.PMID35233009