Hui-Chen Wu, DrPH

Dr. Wu's research focuses on the development of laboratory methods for the detection of human exposure to environmental carcinogens and their use in molecular epidemiology studies. In particular, her research centers around developing and optimizing novel omics biomarkers for environmental health studies, including microRNA and DNA methylation. Her research investigates the association between environmental exposure and hepatocellular carcinoma (HCC) risk and explore the underlying molecular mechanisms. In addition, her research involves identifying circulating biomarkers, including DNA methylation markers and microRNA gene expression for early detection of liver and breast cancers. She has extensive experience conducting omics studies including Illumina Infinium 27k and 450k CpG HumanMethylation BeadChip, MethylationEPIC arrays, next gene sequencing, whole exome sequencing. She is the the mPI of a grant (U01 ES029660) on DNA repair phenotype for breast cancer risk assessment. The main goal of that study is to integrate a high-throughput phenotypic DNA double-strand repair capacity assay to examine breast cancer risk. In this project, she is leading the second aim, which is to study DNA methylation using targeted bisulfite sequencing in breast cancer genes. She provide viable peripheral blood mononuclear cells for DNA repair phenotype assay.

Research Interests: Molecular epidemiology studies on risk factors for breast cancer and liver cancer