Raul Rabadan, PhD

Assistant Professor
Department of Biomedical Informatics
Center for Computational Biology and Bioinformatics 
Columbia University College of Physicians and Surgeons
Phone: 212.851.5141 
Email: rr2579@columbia.edu

EDUCATION & TRAINING
 

• Autonoma University, Madrid, Spain, M.Sc., Theoretical Physics, 1998.
• Autonoma University, Madrid, Spain, Ph.D., Theoretical Physics, 2001.
• CERN, European Organization for Nuclear Research, Geneva, Switzerland. Fellow, Theoretical Physics Unit, 2001-2003.
• Institute for Advanced Study, Princeton University. Theoretical Physics Group, 2003-2006.
• The Simons Center for Systems Biology, Institute for Advanced Study, Princeton University. Member, 2006-2008.
• Department of Biomedical Informatics, Center for Computational Biology and Bioinformatics, Columbia University College of Physicians and Surgeons. Assistant Professor, 2008-present.

BIO

Raul Rabadan is an Assistant Professor in the Department of Biomedical Informatics and in the Center for Computational Biology and Bioinformatics, at the Columbia University College of Physicians and Surgeons. Dr. Rabadan has been the Martin A. and Helen Chooljian Member at The Simons Center for Systems Biology at the Institute for Advanced Study in Princeton, New Jersey. From 2001 to 2003 he was a fellow at the Theoretical Physics Division at CERN, the European Organization for Nuclear Research, in Geneva, Switzerland. In 2003 he joined the Physics Group of the School of Natural Sciences at the Institute for Advanced Study. Dr. Rabadan’s current interest focuses on patterns of evolution in biological systems, in particular, RNA viruses.

SCIENTIFIC INTERESTS

The amount of high throughput data in biological and clinical systems, from Next Generation Sequencing to Electronic Health Records, is increasing dramatically, allowing the development of a quantitative understanding of complex systems. Dr. Rabadan has an interdisciplinary team interested in developing and implementing mathematical and computational tools to extract biological and clinical relevant information from large data sets.

His lab's work is mainly centered around three different topics:

Infectious diseases. Evolution is a dynamical process that shape genomes. His team at Columbia is developing tools to analyze genomic data, extracting the relevant information to understand the molecular biology, population genetics, evolution, and epidemiology of viruses.
Cancers. Next Generation Sequencing technologies provide an extraordinary opportunity to identify somatic mutations that contribute to the development of tumors. His team is developing algorithms to identify driver mutations from high throughput sequence data.
Electronic Health Records. Clinical databases constitute a rich and complex source of high throughput data. His team develops and implements statistical methods to extract relevant clinical information and generate medical knowledge.

SELECTED PUBLICATIONS

• Trifonov V, Khiabanian H, Rabadan R. Geographic Dependence, Surveillance, and Origins of the 2009 Influenza A (H1N1) Virus. New England Journal of Medicine 2009 May 28; 360 (22). 
• P. Vlierberghe, T. Palomero, H. Khiabanian, J. Van der Meulen, M. Castillo, N. Van Roy, B. De Moerloose, J. Philippé, S. González-García, M. L Toribio, T. Taghon, L. Zuurbier, B. Cauwelier, C. J Harrison, C. Schwab, M. Pisecker, S. Strehl, A. W Langerak, J. Gecz, E. Sonneveld, R. Pieters, E. Paietta, J. Rowe, P. H. Wiernik, Y. Benoit, J. Soulier, B. Poppe, X. Yao, C. Cordon-Cardo, J. Meijerink, R. Rabadan, F. Speleman and A. Ferrando. PHF6 mutations in T-cell acute lymphoblastic leukemia. Nature Genetics, 2010, 42: 338-42. doi:10.1038/ng.542.
• Hossein Khiabanian, Pieter Van Vlierberghe, Teresa Palomero, Adolfo A. Ferrando, Raul Rabadan. ParMap, an Algorithm for the Identification of Complex Genomic Variations in Nextgen Sequencing Data.  
• Nature Proceedings, 2010, hdl:10101/npre.2010.4145.1.
• Solovyov A, Palacios G, Briese T, Lipkin WI, Rabadan R (2009) Cluster analysis of the origins of the new influenza A(H1N1) virus. Euro Surveil, 2009 May 28;14(21). pii: 19224.
• Trifonov V, Khiabanian H, Greenbaum B, Rabadan R. The origin of the recent swine influenza A(H1N1) virus infecting humans. Euro Surveill. 2009; 14(21).
• Alexander Solovyov*, Benjamin Greenbaum*, Gustavo Palacios, W. Ian Lipkin and Raul Rabadan (*Joint First Authors). Host Dependent Evolutionary Patterns and the Origin of 2009 H1N1 Pandemic Influenza. PLoS Curr Influenza. 2010 Jan 29:RRN1147.

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