Cohen Lab on Aging, Systems and Statistics

Publications

Selected Publications

  1. Senior, A.M., Legault, V., Lavoie, F.B., Presse, N., Gaudreau, P., Turcot, V., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J., Cohen, A.A. (2022). Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biology, 20(1): 196. https://doi.org/10.1186/s12915-022-01395-z(link is external and opens in a new window)
  2. Cohen, A.A., Ferrucci, L., Fülöp, T., Gravel, D., Hao, N., Kriete, A., Levine, M.E., Lipsitz, L.A., Olde Rikkert, M.G.M., Rutenberg, A., Stroustrup, N., Varadhan, R. (2022). A Complex Systems Approach to Aging Biology. Nature Aging, 2, 580–591. https://doi.org/10.1038/s43587-022-00252-6(link is external and opens in a new window)
  3. Cohen, A.A., Leung, D.L., Legault, V., Gravel, D., Blanchet, F.G., Côté, A.M., Fulop, T., Lee, J., Dufour, F., Liu, M., Nakazato, Y. (2022). Synchrony of biomarker variability indicates a critical transition: Application to mortality prediction in hemodialysis. iScience, 25(6): 104385. https://doi.org/10.1016/j.isci.2022.104385(link is external and opens in a new window)
  4. Wensink, M.J., Cohen, A.A*. (2022). The Danaid Theory of Aging. Frontiers in Cell and Developmental Biology, 9:671208. https://doi.org/10.3389/fcell.2021.671208(link is external and opens in a new window). *Both authors contributed equally to this work.
  5. Cohen, A.A., Leblanc, S., Roucou, X. (2021). Robust physiological metrics from sparsely sampled networks. Front. Physiol, 12:624097. https://doi.org/10.3389/fphys.2021.624097(link is external and opens in a new window)
  6. Cohen, A.A., Legault, V., Fulop, T. (2020). What if there’s no such thing as “aging”? Mechanisms of Ageing and Development, 192:111344. https://doi.org/10.1016/j.mad.2020.111344(link is external and opens in a new window)
  7. Cohen, A.A., Kennedy, BK., Anglas, U., Bronikowski, AM., Deelen, J., Dufour, F., Ferbeyre, G., Ferrucci, L., Franceschi, C., Frasca, D., Friguet, B., Gaudreau, P., Gladyshev VN., Gonos, ES., Gorbunova, V., Gut, P., Ivancheko, M., Legault, V., Lemaître, J-F., Liontis, T., Liu, G-H., Liu, M., Maier, AB., Nobrega, OT., Rikkert, M., Pawelec, G., Rheault, S., Senior, AM., Simm, A., Soo, S., Traa, A., Ukraintseva, S., Vanhaelen, Q., Raamsdonk, J., Witkowski, J., Yashin, A., Ziman, R., Fulop, T. (2020). Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mechanisms of Ageing and Development, 191:111316. https://doi.org/10.1016/j.mad.2020.111316(link is external and opens in a new window)
  8. Cohen, A.A., Levasseur M, Raina P, Fried LP, Fülöp T. (2020). Is aging biology ageist? Journal of Gerontology: Biological Sciences, 75(9): 1653-1655. https://doi.org/10.1093/gerona/glz190(link is external and opens in a new window)
  9. Cohen, A.A., Coste, C., Li, X-Y, Bourg, S., and Pavard, S. (2020). Are trade-offs really the key drivers of aging and lifespan? Functional Ecology, 34(1):153–166. https://doi.org/10.1111/1365-2435.13444(link is external and opens in a new window)
  10.  Dansereau, G., Wey, T.W., Legault, V., Brunet, M.A., Kemnitz, J.W., Ferrucci, L., Cohen, A.A. (2019). Conservation of physiological dysregulation signatures of aging across primates. Aging Cell, 18(2): e12925. https://doi.org/10.1111/acel.12925(link is external and opens in a new window)
  11. Cohen, A.A., Legault, V., Fuellen, G., Fulop, T., Fried, L.P., Ferrucci, L. (2018). The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations. Experimental Gerontology, 107: 11-17. https://doi.org/10.1016/j.exger.2017.07.011(link is external and opens in a new window)
  12. Cohen, A.A., Isaksson, C., Salguero-Gómez, R. (2017). Co-existence of multiple trade-off currencies has major impacts on evolutionary outcomes. PLOS ONE, 12(12):e0189124. https://doi.org/10.1371/journal.pone.0189124(link is external and opens in a new window)
  13. Cohen, A.A. (2017). Aging across the tree of life: the importance of a comparative perspective for the use of animal models in aging. BBA - Molecular Basis of Disease, 1864:2680-2689. https://doi.org/10.1016/j.bbadis.2017.05.028(link is external and opens in a new window)
  14. Cohen, A.A. (2016). Complex systems dynamics in aging: new evidence, continuing questions. Biogerontology, 17(1):205-20. https://doi.org/10.1007/s10522-015-9584-x(link is external and opens in a new window)
  15. Li, Q., Wang, S., Milot, E., Bergeron, P., Ferrucci, Fried, L.P., Cohen, A.A. (2015). Homeostatic dysregulation proceeds in parallel in multiple physiological systems. Aging Cell, 14(6):1103-12. https://doi.org/10.1111/acel.12402(link is external and opens in a new window)
  16. Cohen, A.A., Milot, E., Li, Q., Bergeron, P., Poirier, R., Dusseault-Bélanger, F., Fulop, T., Leroux, M., Legault, V., Metter, E.J., Fried, L.P., Ferrucci, L. (2015). Detection of a novel, integrative aging process suggests complex physiological integration. PLoS ONE, 10(3): e0116489. https://doi.org/10.1371/journal.pone.0116489(link is external and opens in a new window)
  17. Barnwell-Ménard, JL., Li, Q., and Cohen, A.A. (2015). Effects of categorization method, regression type, and variable distribution on the inflation of Type-I error rate when categorizing a confounding variable. Statistics in Medicine, 34(6): 936-949. https://doi.org/10.1002/sim.6387(link is external and opens in a new window)
  18. Milot, E., Cohen, A.A., Vézina, F., Buehler, D. M., Matson, K. D. & Piersma, T. (2014). A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation. Methods in Ecology and Evolution, 5: 146-155. https://doi.org/10.1111/2041-210X.12145(link is external and opens in a new window)
  19. Morrisette-Thomas, V., Cohen, A.A., Fulop, T., Riesco, E., Legault, V., Li, Q., Milot, E., Dusseault-Bélanger, F., Ferrucci, L. (2014). Inflammaging does not simply reflect increases in pro‐inflammatory markers. Mechanisms of Ageing and Development, 139: 49-57. https://doi.org/(link is external and opens in a new window)10.1016/j.mad.2014.06.005(link is external and opens in a new window)
  20. Cohen, A.A., Milot, E., Li Q., Legault, V., Fried, L.P., Ferrucci, L. (2014). Cross-population validation of statistical distance as a measure of physiological dysregulation during aging. Experimental Gerontology, 57; 203-210. https://doi.org/10.1016/j.exger.2014.04.016(link is external and opens in a new window)
  21. Cohen, A.A., Milot, E., Yong, J., Seplaki, C.L., Fulop, T., Bandeen-Roche, K. & Fried, L. P. (2013). A Novel Statistical Approach Shows Evidence for Multi-system Physiological Dysregulation During Aging. Mechanisms of Ageing and Development, 134(3-4):110-7. https://doi.org/10.1016/j.mad.2013.01.004(link is external and opens in a new window)
  22. Cohen, A.A., Martin, L.B., Wingfield, J.C., McWilliams, S.R. (2012). Physiological Regulatory Networks: Ecological Roles and Evolutionary Constraints. Trends in Ecology and Evolution 27 (8): 428-435. https://doi.org/10.1016/j.tree.2012.04.008(link is external and opens in a new window)
  23. Cohen, A.A., McGraw, K.J., Wiersma, P., Williams, J.B., Robinson, W.D., Robinson, T.R., Brawn, J.D., and Ricklefs, R.E. (2008). Interspecific Associations Between Circulating Antioxidant Levels and Life History Variation in Birds. The American Naturalist 172(2): 178-193. https://doi.org/10.1086/589456(link is external and opens in a new window)
  24. Cohen, A.A. (2004). Female Post-Reproductive Lifespan: A General Mammalian Trait. Biological Reviews, 79: 733-750. https://doi.org/10.1017/s1464793103006432(link is external and opens in a new window)

 

PubMed Bibliography(link is external and opens in a new window)