Scientific Papers

An evaluation of in utero polycyclic aromatic hydrocarbon exposure on the neonatal meconium microbiome; December 2024

Divya Keerthy , Miranda J. Spratlen , Lingsheng Wen , Dwayne Seeram , Heekuk Park , Lehyla Calero , Anne-Catrin Uhlemann , Julie B. Herbstman 

In utero exposure to environmental polycyclic aromatic hydrocarbon (PAH) is associated with neurodevelopmental impairments, prematurity and low birthweight. The gut microbiome serves as an intermediary between self and external environment; therefore, exploring the impact of PAH on microbiota may elucidate their role in disease. Here, we evaluated the effect of in utero PAH exposure on meconium microbiome.

NIH Study Finds Exposure to Flame-Retardant Chemicals During Pregnancy Was Associated with Varying Childhood Obesity Risks; November 4, 2024 (Press release en español)

Study reveals a complex link between pregnancy exposure to common chemicals and childhood obesity, researchers say.

Exposure to organophosphate esters (OPEs)—chemicals found in everyday products that use plastics and flame retardants—during pregnancy may have varying effects on the risks of childhood obesity, according to a new study funded by the Environmental influences on Child Health Outcomes (ECHO) Program at the National Institutes of Health.

Clean Air and Climate Policies Provide Health Benefits to New Yorkers, October 17, 2024 (Press Release en español)

A new study analyzes the links between the enactment of major air pollution and climate policies in New York City and significant improvement in air quality from 1998 to 2021. It finds a cumulative beneficial effect of these policies both city-wide and among residents in communities disproportionately affected by air pollution.

Kathleen Lau, Jia Guo, Yuqi Miao, Zev Ross, Kylie W. Riley, Shuang Wang, Julie Herbstman, Frederica Perera

The study by environmental health scientists at Columbia University Mailman School of Public Health is published in the peer-reviewed journal Frontiers in Public Health

Researchers Publish Overview of Existing Chemical Exposure Research using ECHO Cohort Data; September 24, 2024

Emily S Barrett, Jennifer L Ames, Stephanie M Eick, Alicia K Peterson, Zorimar Rivera-Núñez, Anne P Starling, Jessie P Buckley and  among ECHO  Consortium includes Julie Herbstman

 

While specific environmental chemical exposures have been proven to impact child well-being, exposure studies are often limited in size and diversity, limiting the ability to draw generalizable conclusions from results. With data from more than 60,000 participants from 69 groups of pregnant participants, the ECHO program is the largest study of U.S. children’s health and a unique opportunity for more-representative research.

Polycyclic aromatic hydrocarbon exposure effects on trajectories of maternal and adolescent mental health; September 11, 2024

Mariah DeSerisy, Leilani Salas, Emiliya Akhundova, Dahiana Pena, Jacob W Cohen, David Pagliaccio, Julie Herbstman, Virginia Rauh, Amy E Margolis 

PAH exposure has detrimental impacts on both maternal and child mental health.

Our study extends previous work by examining trajectories of PAH-related maternal demoralization symptoms and adolescent mental health. Our findings support an intergenerational transmission of PAH-related psychological distress such that mothers exposed to PAH during pregnancy are more likely to demonstrate higher demoralization over time and in turn their children report higher mental and behavioral health symptoms.

Neighborhood Impact on Children’s Well-Being Shifted During COVID-19 Pandemic, ECHO Study Suggests; July 2024

The COVID-19 pandemic significantly disrupted daily life and has raised concerns about its impact on children’s well-being. A new study from the NIH Environmental influences on Child Health Outcomes Program (ECHO) sheds light on how a neighborhood’s physical and social environment influenced a child’s well-being before and during the pandemic.  Read Full Publication: Environmental Research

Modeling Air Pollution-Related Health Benefits of Transportation Scenarios: A Collaboration Between Academic Researchers and Environmental Justice Organizations; (Por Sarah Derouin, articulo Press Release en español)

Co-authors in EJ/academic partnership include Dr. Frederica Perera, Katy Coomes, and Kathleen Lau, CCCEH Team First published: 30 July 2024

Transportation is a leading contributor to emissions and is a focus for climate policies. Traffic-related air pollution disproportionately affects environmental justice (EJ) communities, but health impact assessments rarely center EJ issues or prioritize the concerns of EJ communities. Community Science https://doi.org/10.1029/2023CSJ000041

 

New ECHO Research Investigates Relationship Between Phthalate Exposure and High Blood Pressure, Related Complications During Pregnancy; (Press Release en español)

Julie B. Herbstman contributing author; Posted on June 5, 2024

Collaborative ECHO research led by John Meeker, ScD of the University of Michigan, and Jordan Kuiper, PhD of George Washington University, investigates the relationship between phthalate exposure and high blood pressure during pregnancy. This research, titled “Urinary concentrations of phthalate metabolites in relation to preeclampsia and other hypertensive disorders of pregnancy in the Environmental influences on Child Health Outcomes (ECHO) program,” is published in Environment International.

Protecting the Developing Brains of Children from the Harmful Effects of Plastics and Toxic Chemicals in Plastics, April 2024

Recommendations for Essential Policy Reforms in the New Global Treaty on Plastics

Project TENDRA authors include Dr. Frederica Perera and research referenced includes Dr. Julie Herbstman and others at the Columbia Mailman School of Public Health Environmental Health Sciences Department. As experts in the effects of toxic chemicals on neurodevelopment, and as scientists, clinicians, and children’s health advocates in Project TENDR (Targeting Environmental NeuroDevelopment Risks), we are deeply concerned about mounting scientific evidence showing that plastics and toxic chemicals in plastics are contributing to neurodevelopmental disabilities and cognitive deficits in children. We summarize the evidence of widespread fetal and early childhood exposures to plastics and resulting harm to children’s brains and offer recommendations to strengthen the global treaty on plastics pollution to ensure it addresses the toxicity and proliferation of plastics and petrochemicals.

Climate Policies to Reduce Motor Vehicle Emissions Can Improve Children’s Health (Press release en español)

A new study finds that policies to reduce carbon dioxide (CO₂) emissions from motor vehicles combined with investments in electric vehicles and public transportation would reduce air pollution and bring large benefits to children’s health. They would also save money. Environmental Research Letters; Alique G Berberian, Frederica Perera, Saravanan Arunachalam, Jonathan I Levy, Laura Buckley, Calvin Arter, Kaitlyn E Coomes and Jonathan J Buonocore; March 13, 2024

Curbing Coal Emissions Translates to Health Gains for Children

Residential heating by coal has for decades been the major contributor to the high levels of air pollution in Krakow, Poland. New research finds a nearly 40 percent decline in the annual average concentration of respirable particulate matter (PM_2.5)  in Kraków, Poland, between 2010 and 2019 following the implementation of policies targeting emissions from the burning of coal and other solid fuels. Researchers show the improvement in air quality translated to substantial benefits for children’s outcomes, including fewer cases of asthma and better birth outcomes. Environmental Research Letters Agnieszka Pac, Renata Majewska, Natalia Nidecka, Elzbieta Sochacka-Tatara and Frederica P Perera; March 13, 2024

Indoor Temperature and Energy Insecurity: Implications for Prenatal Health Disparities in Extreme Heat Events

Extreme heat events are a major public health concern and are only expected to increase in intensity and severity as climate change continues to accelerate. Pregnant people are physiologically more vulnerable to the effects of extreme heat, and exposure can induce harm on both the pregnant person and the fetus. Enviornmental Health Perspectives; Gabriella Y. Meltzer , Pam Factor-Litvak, Julie B. Herbstman, Blair J. Wylie, and Diana Hernández; March 6, 2024

ECHO Researchers Find Link Between Phthalate Exposure and Preterm Birth, Estimate Potential Costs; (Press Release en español)

Julie B. Herbstman contributing author; Posted on February 19, 2024

Collaborative ECHO research led by Leonardo Trasande, MD, MPP of NYU Langone Health investigates the potential connections between phthalates, their metabolites in the urine of pregnant individuals, and birth outcomes. This research, titled “Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs,” is published in The Lancet Planetary Health.

ECHO NIH STUDY FINDS FLAME-RETARDANT CHEMICALS MAY INCREASE RISK OF PRETERM BIRTH, HIGHER BIRTH WEIGHT; (Press release en español)

Julie B. Herbstman contributing author; Environmental Health Perspectives; January 25, 2024

An NIH Environmental influences on Child Health Outcomes (ECHO) Cohort study finds that certain organophosphate esters (OPEs) were linked to increased odds of preterm birth, especially in girls.Pregnant individuals exposed to specific classes of flame-retardant chemicals known as organophosphate esters (OPEs) may face an increased risk of preterm birth, especially for baby girls, or higher birth weights for girls and boys, according to a recently published study funded by the Environmental influences on Child Health Outcomes (ECHO) Program at the National Institutes of Health.

Replacement flame retardant chemicals linked to preterm birth, new study finds EWG ; Alex Friedman, Ph.D. February 5, 2024

A new study finds a link between premature birth and exposure to organophosphate ester flame retardants, or OPEs, used in furniture and foam for mattresses and more. The study also found the risk of preterm birth was greater for pregnant people who gave birth to female babies.

Outdoor Monitors that Capture Fine Particulate Matter, (PM2.5) Insufficiently Explain Personal Exposure to PAH

To understand how chemical exposure can impact health, researchers need tools that capture the complexities of personal chemical exposure in addition to outdoor stationary monitors such as AQI, air quality index and Hazard Mapping System (HMS), smoke density data from satellites.

LisaM.Bramer, HollyM.Dixon, DianaRohlman, RichardP.Scott, Rachel L.Miller,  LaurelKincl, JulieB.Herbstman,KatrinaM.Waters and KimA.Anderson; January 22,2024

Wristband Monitors Provide Detailed Account of Air Pollution Exposure (Press release en español)

The researchers examined an unprecedented number of 61 air pollution compounds known as polycyclic aromatic hydrocarbons (PAHs) and compared them to 75 questionnaire variables, making the study the most comprehensive analysis of its kind. PAHs are created by combustion and can be found in sources like automotive exhaust and tobacco smoke; exposure to these compounds has been linked to various adverse health effects, including those related to fetal growth and neurodevelopment. The study’s findings appear online in the Journal of Exposure Science & Environmental Epidemiology. Sarah M. McLarnan, Lisa M. Bramer, Holly M. Dixon , Richard P. Scott , Lehyla Calero, Darrell Holmes, Elizabeth A. Gibson, Haleigh M. Cavalier, Diana Rohlman, Rachel L. Miller , Laurel Kincl, Katrina M. Waters, Kim A. Anderson and Julie B. Herbstman; January 5, 2024

Trajectory analysis of rhinitis in a birth cohort from lower-income NYC neighborhoods (Press release en español)

Nasal symptoms including congestion, runny nose, itching and/or sneezing may be a sign of rhinitis. Rhinitis is a prevalent, chronic nasal condition associated with asthma.To better understand and characterize the developmental course of rhinitis and how it may shed light as an early predictor of asthma, the study examined the course of rhinitis from infancy to adolescence. CCCEH’s longitudinal birth cohort participated in the study. Children who experienced "persistent and late onset", and /or "frequent" rhinitis are associated with increased risk of asthma diagnosis and symptoms during adolescence. The findings inform us that children experiencing repeat or persistent rhinitis symptoms early in life may warrant more vigilant monitoring for asthma symptoms and asthma triggers. Developing interventions aimed at the prevention, early diagnosis, and/or treatment of rhinitis could potentially avoid subsequentasthma development. Flores NM, Lovinsky-Desir S, Divjan A, Hoepner LA, Zou J, Miller RL, Herbstman JB, Perera FP, Perzanowski MS, Chen Q, The Journal of Allergy and Clinical Immunology December 15, 2023

Association between mitochondrial bio markers, urban residential exposures and childhood asthma outcomes over 6 months (Press release en español)

Determining biomarkers of these responses to exposures and evaluating whether they predict worse lung function or higher airway inflammation may help optimize environmental and medical approaches to childhood asthma. Miller RL, Rivera J, Lichtiger L, Govindarajulu US, Jung KH, Lovinsky-Desir S, Perera F, Balcer Whaley S, Newman M, Grant TL, McCormack M, Perzanowski M, Matsui, E.C.; Enviornmental Research, December 15, 2023

Life satisfaction for adolescents with developmental and  behavioral disabilities during the COVID-19 pandemic

This study aimed to identify contextual factors associated with life satisfaction during the COVID-19 pandemic for adolescents with mental, emotional, behavioral, and developmental (MEBD) disabilities. Conclusion: Findings from this study highlight the importance of interventions aimed specifically at increasing adolescent social connectedness, family engagement, and access to medical support for adolescents with MEBD disabilities, particularly in the face of stressors, such as a global pandemic. Sherlock P, Mansolf M, Blackwell CK, Blair C, Cella D, Deoni S, Fry RC, Ganiban J, Gershon R, Herbstman JB, Lai JS, Leve LD, LeWinn KZ, Margolis AE, Miller EB, Neiderhiser JM, Oken E, O'Shea TM, Stanford JB, Zelazo; Pediatric Research; October 24, 2023

Factors that influence environmental health literacy from returning polycyclic aromatic hydrocarbon exposure results

Environmental health literacy (EHL) is an emerging field that combines elements from different disciplines, including health literacy, risk communication, environmental health, communications research, and safety culture. Building on the concept of health literacy, as EHL increases, it is anticipated that informed individuals can take control of their own health and be aware of how their actions may reduce exposure or mitigate risk from environmental hazards. Kylie W Riley, Kimberly Burke, Anabel Cole, Maricela Ureno, Holly M Dixon, Lehyla Calero, Lisa M Bramer, Katrina M Waters, Kim A Anderson, Julie B Herbstman, and Diana Rohlman; International Public Health Journal; September 26, 2023

Science News, Climate change puts children's health at risk now and in the future

Heat Waves, wildfires, and other climate related effects on the environment are particularly hard on children's physical and mental health. Aimee Cunnigham, August 3, 2023

Study Finds Most U.S. Children Use Potentially Toxic Makeup Products, Often During Play (Press Release en español) 

Children Can be Exposed to Lead, Asbestos, and Other Toxic Chemicals Through Use of Makeup and Body Products

A study by scientists at Columbia University Mailman School of Public Health and Earthjustice found that most children in the United States use makeup and body products that may contain carcinogens and other toxic chemicals.

Results are published in the peer-reviewed International Journal of Environmental Research and Public Health.  

The study, based on more than 200 surveys, found that 79 percent of parents say their children 12 or younger use makeup and body products marketed to children, like glitter, face paint, and lip gloss.

Prior research has shown that these products often have toxic chemicals, like lead, asbestos, PFAS, phthalates, and formaldehyde in them. Toxic chemicals found in children’s makeup and body products (CMBP), like heavy metals, are especially harmful to infants and children. These chemicals, whether intentionally added or present as contaminants, have been linked to cancer, neurodevelopmental harm, and other serious and irreversible health effects.

Medley, E.A.; Kruchten, K.E.; Spratlen, M.J.; Ureño, M.; Cole, A.; Joglekar, R.; Herbstman, J.B. Usage of Children’s Makeup and Body Products in the United States and Implications for Childhood Environmental Exposures. Int. J. Environ. Res. Public Health January 24, 2023, 20, 2114. https://doi.org/10.3390/ijerph20032114

Cap and Invest Policy Could Pay Dividends for Children's Health: Study (Press Release en Español)

A cap-and-invest strategy to cut transportation-related carbon emissions could provide substantial health benefits to children in New York City, with greater benefits among Black and Hispanic children. The results of the study by researchers at Columbia University Mailman School of Public Health are published in Environmental Research.

Kaitlyn E. Coomes, Jonathan J. Buonocore, Jonathan I. Levy, Calvin Arter, Saravanan Arunachalam, Laura Buckley, Alique Berberian, Jonathan Gunasti, Frederica Perera,
Assessment of the health benefits to children of a transportation climate policy in New York City, Environmental Research, 2022,114165, ISSN 0013-9351,
https://doi.org/10.1016/j.envres.2022.114165. Online September 7, 2022

New York City Switch to Clean Buses Cut Air Pollution (Press Release en Español)

The transition of the Metropolitan Transportation Authority (MTA) bus fleet in New York City to cleaner fuels and engines was followed by declines in air pollution, particularly nitrous oxide. The study was led by scientists at Columbia University Mailman School of Public Health, CCCEH, Columbia Irving Medical Center, and Drexel University Dornsife School of Public Health. The findings are published in the Journal Of Exposure Science And Environmental Epidemiology.

Gina S. Lovasi1 , Christian A. Treat1,2, Dustin Fry 1✉, Isha Shah3 , Jane E. Clougherty3,4, Alique Berberian3 , Frederica P. Perera3,5 and Marianthi-Anna Kioumourtzoglou5, Journal of Exposure Science & Environmental Epidemiology; https://doi.org/10.1038/s41370-022-00454-5.Online July 20, 2022.

Climate Change, Fossil - Fuel Pollution and Children's Health (Press Release en Español)

The combustion of fossil fuels (coal, petroleum [oil], and natural gas) is the major source of both air pollution and the greenhouse-gas emissions driving climate change. The fetus, infant, and child are especially vulnerable to exposure to air pollution and climate change, which are already taking a major toll on the physical and mental health of children. Given the frequent co-occurrence of various fossil-fuel exposures, their interactions and cumulative environmental impacts are a growing concern. All children are at risk, but the greatest burden falls on those who are socially and economically disadvantaged. Protection of children’s health requires that health professionals understand the multiple harms to children from climate change and air pollution and use available strategies to reduce these harms.

Perera, Frederica Dr.P.H., Ph.D., Nadeau,  Kari M.D., Ph.D.  Solomon, Caren G., M.D., M.P. H.,Editor, Salas, Renee, N. M.D., M.P.H., Guest Editor 16 June 2022; N Engl J Med 2022; 386:2303-2314; DOI: 10.1056/NEJMra2117706,Published online, July 20, 2022.

Prenatal exposure to air pollution is associated with altered brain structure, function, and metabolism in childhood

Prenatal exposure to air pollution disrupts cognitive, emotional, and behavioral development. The brain disturbances associated with prenatal air pollution are largely unknown. In this prospective cohort study, we estimated prenatal exposures to fine particulate matter (PM_2.5) and polycyclic aromatic hydrocarbons (PAH), and then assessed their associations with measures of brain anatomy, tissue microstructure, neurometabolites, and blood flow in 332 youth, 6–14 years old. We then assessed how those brain disturbances were associated with measures of intelligence, ADHD and anxiety symptoms, and socialization.

Bradley S. Peterson, Ravi Bansal, Siddhant Sawardekar, Carlo Nati, Eman R. Elgabalawy, Lori A. Hoepner, Wanda Garcia, Xuejun Hao, Amy Margolis, Frederica Perera, Virginia Rauh; Journal of Child Psychology and Psychiatry; First published: 14 February 2022 https://doi.org/10.1111/jcpp.13578

Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study

Previously, we found that reported infant rhinorrhea and watery eyes without a cold (RWWC) predicted school age exercise-induced wheeze, emergency department visits, and hospitalizations. These findings were independent of allergic sensitization, and we theorized that increased parasympathetic tone underlay the association. We also reported that increased heart-rate variability (HRV) in infants predicted wheeze in 2– 3 year-olds. In a convenience sample of children participating in a birth cohort study, we tested the hypothesis that infants with RWWC would have elevated HRV, indicating increased parasympathetic tone.

Laura A Conrad, Natalie Buchinsky, Luis M Acosta, J David Nugent, Khalil W Savary, Rachel L Miller, Nurdant Emanet, Julie Herbstman,  Beatrice Beebe, Michael M Myers, William P Fifer, Matthew S Perzanowski. 9 November 2021 Volume 2021:14 Pages 1349—1354. 

Prenatal environmental tobacco smoke exposure alters children's cognitive control circuitry: A preliminary study

Our findings suggest that maternal ETS exposure during pregnancy has deleterious effects on the structure and function of cognitive control circuitry which in turn affects attentional capacity in school-age children. These findings are consistent with prior findings documenting the effects of active maternal smoking on chidlren's neurodevleoment, pointing to the neurotixicity of nicotine regardless of exposure pathway.

Margolis AE, Pagliaccio D, Ramphal B, Banker S, Thomas L, Robinson M, Honda M, Sussman T, Posner J, Kannan K, Herbstman J, Rauh V, Marsh R. Prenatal environmental tobacco smoke exposure alters children's cognitive controlcircuitry: A preliminary study. Environ Int. 2021 Oct;155:106516. doi:10.1016/j.envint.2021.106516. Epub 2021 May 6. PMID: 33964643; PMCID:PMC8292185.

Telomere dynamics across the early life course: Findings from a longitudinal study in children

Telomeres are protective caps on chromosome ends that shorten with each cell division. Telomere length (TL) predicts the onset of cellular senescence and correlates with longevity and age-related disease risk. Previous research suggests that adults display fixed ranking and tracking of TL by age 20 years, supporting the importance of TL at birth and attrition during childhood. However, longitudinal research examining telomere dynamics during early life is sparse. Here, we used monochrome multiplex quantitative polymerase chain reaction to measure relative TL in leukocytes isolated from cord blood and child blood collected at ages 3, 5, 7, and 9 years among 224 minority children enrolled in a New York City-based birth cohort. We also measured maternal TL at delivery in a subset of 197 participants with a biobanked blood sample. TL decreased most rapidly in the first years of life (birth to 3 years), followed by a period of maintenance into the pre-puberty period. 

Cowell W, Tang D, Yu J, Guo J, Wang S, Baccarelli AA, Perera F, Herbstman JB. Telomere dynamics across the early life course: Findings from a longitudinalstudy in children. Psychoneuroendocrinology. 2021 Jul;129:105270. doi:10.1016/j.psyneuen.2021.105270. Epub 2021 May 14. PMID: 34020264; PMCID: PMC8217283.

Exploring associations between prenatal exposure to multiple endocrine disruptors and birth weight with exposure continuum mapping

Improved understanding of how prenatal exposure to environmental mixtures influences birth weight or other adverse outcomes is essential in protecting child health. We illustrate a novel exposure continuum mapping (ECM) framework that combines the self-organizing map (SOM) algorithm with generalized additive modeling (GAM) in order to integrate spatially-correlated learning into the study mixtures of environmental chemicals. We demonstrate our method using biomarker data on chemical mixtures collected from a diverse mother-child cohort.

Pearce JL, Neelon B, Bloom MS, Buckley JP, Ananth CV, Perera F, Vena J, Hunt K; program collaborators for Environmental influences on Child Health Outcomes. Exploring associations between prenatal exposure to multiple endocrine disruptors and birth weight with exposure continuum mapping. Environ Res. 2021 Jun 2;200:111386. doi: 10.1016/j.envres.2021.111386. Epub ahead of print. PMID: 34087191.

Prenatal exposure to air pollution is associated with childhood inhibitory control and adolescent academic achievement (En Español)

Prenatal air pollution exposure is associated with reductions in self-regulation and academic achievement. Self-regulation has been separately linked with academic achievement. Understudied, however, are the contributions of pollution exposure to inhibitory control, a facet of self-regulation, and whether pollution-related inhibitory control deficits are associated with impairment in academic achievement.

Amy E. Margolis, Bruce Ramphal, David Pagliaccio, Sarah Banker, Ena Selmanovic, Lauren Thomas, Pam Factor-Litvak, Frederica Perera, Bradley S. Peterson, Andrew Rundle, Julie Herbstman, Jeff Goldsmith, Virginia Rauh, Prenatal exposure to air pollution is associated with childhood inhibitory control and adolescent academic achievement,Environmental Research, 2021,111570, ISSN 0013-9351, https://doi.org/10.1016/j.envres.2021.111570.(https://www.sciencedirect.com/science/article/pii/S0013935121008641)

Telomere Length, a Longevity Measure, May Be Determined Early in Life (En Español)

A new research study finds that telomeres shorten most rapidly during early childhood, replicating, for the first time, studies done in animal models.

Telomeres are protective caps on DNA that shorten as we grow older. Now, one of the first studies to examine telomere length (TL) in childhood finds that the initial setting of TL during prenatal development and in the first years of life may determine one’s TL throughout childhood and potentially even into adulthood or older age. The study also finds that TL decreases most rapidly from birth to age 3, followed by a period of maintenance into the pre-puberty period, although it was sometimes seen to lengthen.

Citation: Whitney Cowell, Deliang Tang, Jie Yu, Jia Guo, Shuang Wang, Andrea A. Baccarelli, Frederica Perera, Julie B. Herbstman,
Telomere dynamics across the early life course: Findings from a longitudinal study in children, Psychoneuroendocrinology, Volume 129, 2021, 105270, ISSN 0306-4530, https://doi.org/10.1016/j.psyneuen.2021.105270. (https://www.sciencedirect.com/science/article/pii/S030645302100144X)

A methodological pipeline to generate an epigenetic marker of prenatal exposure to air pollution indicators

The field of environmental health has lacked an accessible biomarker to identify newborns at elevated risk as a result of a toxic prenatal exposure, one that is feasible in a small sample of DNA in cord blood or in a bloodspot. Such a biomarker could be used to identify highly exposed newborns at increased risk of adverse outcomes, such as neurodevelopmental problems and other chronic illness, in order to initiate early interventions. 

Citation: Ya Wang , Frederica Perera , Jia Guo , Kylie W. Riley , Teresa Durham , Zev Ross , Cande V. Ananth , Andrea Baccarelli , Shuang Wang & Julie B. Herbstman (2021): A methodological pipeline to generate an epigenetic marker of prenatal exposure to air pollution indicators, Epigenetics, DOI: 10.1080/15592294.2021.1872926, 2021 January 21. 

Potential health benefits of sustained air quality improvements in New York City: A simulation based on air pollution levels during the COVID-19 shutdown

New York City (NYC) experienced a sharp decline in air pollution during the COVID-19 shutdown period (March 15, 2020 to May 15, 2020)-albeit at high social and economic costs. It provided a unique opportunity to simulate a scenario in which the city-wide air quality improvement during the shutdown were sustained over the five-year period, 2021 through 2025, allowing us to estimate the potential public health benefits to children and adults and their associated economic benefits. We focused on fine particulate matter (PM2.5) and modeled potential future health benefits to children and adults. The analysis considered outcomes in children that have not generally been accounted for in clean air benefits assessments, including preterm birth, term low birthweight, infant mortality, child asthma incidence, child asthma hospital admissions and emergency department visits, autism spectrum disorder, as well as adult mortality.

Citation: Perera F, Berberian A, Cooley D, Shenaut E, Olmstead H, Ross Z, Matte T. Potential health benefits of sustained air quality improvements in New York City: A simulation based on air pollution levels during the COVID-19 shutdown. Environ Res. 2021 Feb;193:110555. doi: 10.1016/j.envres.2020.110555. Epub 2020 Dec 4. PMID: 33285156.

Characterizing peak exposure of secondhand smoke using a real-time PM 2.5 monitor

Although short-duration elevated exposures (peak exposures) to pollutants may trigger adverse acute effects, epidemiological studies to understand their influence on different health effects are hampered by lack of methods for objectively identifying peaks. Secondhand smoke from cigarettes (SHS) in the residential environment can lead to peak exposures. The aim of this study was to explore whether peaks in continuous PM2.5 data can indicate SHS exposure. A total of 41 children (21 with and 20 without SHS exposure based on self-report) from 28 families in New York City (NY, USA) were recruited. Both personal and residential continuous PM2.5 monitoring were performed for five consecutive days using MicroPEM sensors (RTI International, USA).

Citation: Zhang T, Chillrud SN, Yang Q, Pitiranggon M, Ross J, Perera F, Ji J, Spira A, Breysse PN, Rodes CE, Miller R, Yan B. Characterizing peak exposure of secondhand smoke using a real-time PM2.5 monitor. Indoor Air. 2020 Jan;30(1):98-107. doi: 10.1111/ina.12611. Epub 2019 Dec 11. PMID: 31610044; PMCID: PMC7137634.

Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO

Air pollution exposure is ubiquitous with demonstrated effects on morbidity and mortality. A growing literature suggests that prenatal air pollution exposure impacts neurodevelopment. We posit that the Environmental influences on Child Health Outcomes (ECHO) program will provide unique opportunities to fill critical knowledge gaps given the wide spatial and temporal variability of ECHO participants.

Citation: Volk HE, Perera F, Braun JM, Kingsley SL, Gray K, Buckley J, Clougherty JE, Croen LA, Eskenazi B, Herting M, Just AC, Kloog I, Margolis A, McClure LA, Miller R, Levine S, Wright R; Environmental influences on Child Health Outcomes. Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO. Environ Res. 2020 Oct 22:110320. doi: 10.1016/j.envres.2020.110320. Epub ahead of print. PMID: 33098817.

The associations between prenatal exposure to polycyclic aromatic hydrocarbon metabolites, umbilical cord blood mitochondrial DNA copy number, and children's neurobehavioral development

Exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy is a risk factor for adverse neurobehavioral development outcomes. Mitochondrial DNA are sensitive to environmental toxicants due to the limited ability of repairing. The change of mitochondrial DNA copy number (mtDNAcn) might be a biologically mechanism linking PAH exposure and children's neurobehavioral impairment. Our aims are to explore whether PAH metabolites in maternal urine were associated with children's neurobehavioral development at 2 years old and umbilical cord blood mtDNAcn, and whether mtDNAcn was a mediator of PAH-related neurobehavioral development. 

COVID-19 Related School Closings and Risk of Weight Gain Among Children

Abstract: The COVID-19 pandemic is causing substantial morbidity and mortality, straining health care systems, shutting down economies, and closing school districts. While it is a priority to mitigate its immediate impact, we want to call attention to the pandemic's longer-term effect on children's health: COVID-19, via these school closures, may exacerbate the epidemic of childhood obesity and increase disparities in obesity risk. 

Citation: Rundle AG, Park Y, Herbstman JB, Kinsey EW, Wang YC. COVID-19 Related School Closings and Risk of Weight Gain Among Children. Obesity (Silver Spring). 2020 Mar 30. doi: 10.1002/oby.22813.

Towards a Fuller Assessment of Benefits to Children's Health of Reducing Air Pollution and Mitigating Climate Change Due to Fossil Fuel Combustion 

Fossil fuel combustion by-products, including particulate matter (PM2.5), polycyclic aromatic hydrocarbons (PAH), nitrogen dioxide (NO2) and carbon dioxide (CO2), are a significant threat to children's health and equality. Various policies to reduce emissions have been implemented to reduce air pollution and mitigate climate change, with sizeable estimated health and economic benefits. However, only a few adverse outcomes in children have been considered, resulting in an undercounting of the benefits to this vulnerable population.

Citation: Shea E, Perera F, Mills D. ; Environmental Research, Elsevier, March 2020

Perinatal phthalates exposure decreases fine-motor functions in 11-year-old girls: Results from weighted Quantile sum regression

Phthalates are a group of high production chemicals, generally used as plasticizers and odor enhancers. Phthalates cross the blood-placenta barrier and are associated with deficits in cognitive functions and behavior problems in offspring. We previously reported sex-specific associations with motor function when phthalates are considered singly. Because exposure to phthalates usually occurs as mixtures, here we assess these associations between a mixture of phthalates and motor function at age 11 years.

Citation: Sharon Daniela,b, Arin A. Balalianc, Robin M. Whyattd, Xinhua Liue, Virginia Rauhf, Julie Herbstmand, Pam Factor-Litva, Environment International, Volume 136, March 2020, 105424

A powerful and flexible weighted distance-based method incorporating interactions between DNA methylation and environmental factors on health outcomes

Abstract: Deoxyribonucleic acid (DNA) methylation plays a crucial role in human health. Studies have demonstrated associations between DNA methylation and environmental factors with evidence also supporting the idea that DNA methylation may modify the risk of environmental factors on health outcomes. 

Citation: Wang Y, Qian M, Tang D, Herbstman J, Perera F, Wang S. A powerful and flexible weighted distance-based method incorporating interactions between DNA methylation and environmental factors on health outcomes, Bioinformatics, Volume 36, Issue 3, 1 February 2020, Pages 653–659, https://doi.org/10.1093/bioinformatics/btz630

​Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood

Abstract: Risk for childhood psychopathology is complex and multifactorial, implicating direct and interacting effects of familial and environmental factors. The role of environmental neurotoxicants in psychiatric risk is of growing concern, including polycyclic aromatic hydrocarbons (PAH), common in air pollution. 

Citation: Pagliaccio D, Herbstman JB, Perera F, Tang D, Goldsmith J, Peterson BS, Rauh V, Margolis AE. Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood. J Child Psychology Psychiatry. 2020 Jan 7. doi: 10.1111/jcpp.13189.

The Association Between Perfluoroalkyl Substances and Lipids in Cord Blood

Abstract: Perfluoroalkyl substances (PFAS) were among various persistent organic pollutants suspected to have been released during the collapse of the World Trade Center (WTC) on 9/11/2001. Evidence suggests that PFAS may have cardiometabolic effects, including alterations in lipid profiles. This study evaluated the association between cord blood PFAS and lipids in a population prenatally exposed to the WTC disaster.

Citation: Miranda J Spratlen, Frederica P Perera, Sally Ann Lederman, Morgan Robinson, Kurunthachalam Kannan, Julie Herbstman, Leonardo Trasande, The Association Between Perfluoroalkyl Substances and Lipids in Cord Blood, The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 1, January 2020, Pages 43–54, https://doi.org/10.1210/clinem/dgz024

Towards a Fuller Assessment of the Economic Benefits of Reducing Air Pollution From Fossil Fuel Combustion: Per-case Monetary Estimates for Children's Health Outcomes 

The Case of Juliana v. U.S. Children and the Health Burdens of Climate Change

On June 4, 2019, the Ninth Circuit Court of Appeals will hear oral arguments in Juliana v. United States to determine whether the case will proceed to trial in district court in Oregon. Nearly 4 years ago, 21 children and adolescents between 8 and 19 years of age, including Kelsey Juliana from Oregon, filed suit against the federal government, charging that the government’s inaction on addressing climate change violated their constitutional right to life, liberty, and property.1 To date, no such lawsuit against the federal government has succeeded in the United States, despite a sharp increase in the number of similar suits filed by young people, municipalities, and state governments. Indeed, none of these lawsuits has gone to trial. As the Juliana plaintiffs argue — and we agree — climate change is the greatest public health emergency of our time and is particularly harmful to fetuses, infants, children, and adolescents.

Citation: Renee N. Salas, M.D., M.P.H., Wendy Jacobs, J.D., and Frederica Perera, Dr.P.H., Ph.D. May 30, 2019 N Engl J Med 2019; 380:2085-2087 DOI: 10.1056/NEJMp1905504